Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kdr  kinase insert domain protein receptor   (Synonyms: Flk1, Flk-1, orv, vascular endothelial growth factor receptor- 2, VEGFR2, VEGFR-2, VEGF receptor-2)
Results	Reference
1	J:233988 Barry DM, Xu K, Meadows SM, Zheng Y, Norden PR, Davis GE, Cleaver O, Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice. Development. 2015 Sep 1;142(17):3058-70
1	J:174608 Chong DC, Koo Y, Xu K, Fu S, Cleaver O, Stepwise arteriovenous fate acquisition during mammalian vasculogenesis. Dev Dyn. 2011 Sep;240(9):2153-65
1	J:177484 Daane JM, Downs KM, Hedgehog signaling in the posterior region of the mouse gastrula suggests manifold roles in the fetal-umbilical connection and posterior morphogenesis. Dev Dyn. 2011 Sep;240(9):2175-93
1*	J:247900 Downs KM, Systematic localization of Oct-3/4 to the gastrulating mouse conceptus suggests manifold roles in mammalian development. Dev Dyn. 2008 Feb;237(2):464-75
1	J:109435 Ema M, Takahashi S, Rossant J, Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood. 2006 Jan 1;107(1):111-7
1	J:296645 Hamline MY, Corcoran CM, Wamstad JA, Miletich I, Feng J, Lohr JL, Hemberger M, Sharpe PT, Gearhart MD, Bardwell VJ, OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the Polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR. Dev Biol. 2020 Jul 18;
1	J:95387 Hiratsuka S, Nakao K, Nakamura K, Katsuki M, Maru Y, Shibuya M, Membrane fixation of vascular endothelial growth factor receptor 1 ligand-binding domain is important for vasculogenesis and angiogenesis in mice. Mol Cell Biol. 2005 Jan;25(1):346-54
1*	J:119027 Inman KE, Downs KM, Brachyury is required for elongation and vasculogenesis in the murine allantois. Development. 2006 Aug;133(15):2947-59
1*	J:287156 Ishitobi H, Matsumoto K, Azami T, Itoh F, Itoh S, Takahashi S, Ema M, Flk1-GFP BAC Tg mice: an animal model for the study of blood vessel development. Exp Anim. 2010;59(5):615-22
1	J:178675 Ishitobi H, Wakamatsu A, Liu F, Azami T, Hamada M, Matsumoto K, Kataoka H, Kobayashi M, Choi K, Nishikawa S, Takahashi S, Ema M, Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse. Development. 2011 Dec;138(24):5357-68
1	J:192712 Meadows SM, Fletcher PJ, Moran C, Xu K, Neufeld G, Chauvet S, Mann F, Krieg PA, Cleaver O, Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
1*	J:198561 Mikedis MM, Downs KM, Widespread but tissue-specific patterns of interferon-induced transmembrane protein 3 (IFITM3, FRAGILIS, MIL-1) in the mouse gastrula. Gene Expr Patterns. 2013 Oct;13(7):225-39
1*	J:56939 Miquerol L, Gertsenstein M, Harpal K, Rossant J, Nagy A, Multiple developmental roles of VEGF suggested by a LacZ-tagged allele. Dev Biol. 1999 Aug 15;212(2):307-22
1*	J:82684 Motoike T, Markham DW, Rossant J, Sato TN, Evidence for novel fate of Flk1+ progenitor: Contribution to muscle lineage. Genesis. 2003 Mar;35(3):153-9
1	J:293500 Reichman DE, Park L, Man L, Redmond D, Chao K, Harvey RP, Taketo MM, Rosenwaks Z, James D, Wnt inhibition promotes vascular specification of embryonic cardiac progenitors. Development. 2018 Jan 8;145(1):dev159905
1	J:96124 Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N, Shibuya M, Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1076-81
1*	J:26846 Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC, Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995 Jul 6;376(6535):62-6
1	J:188649 Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, Ema M, Genome-wide identification of endothelial cell-enriched genes in the mouse embryo. Blood. 2012 Jul 26;120(4):914-23
1*	J:116891 Tanaka M, Okudaira S, Kishi Y, Ohkawa R, Iseki S, Ota M, Noji S, Yatomi Y, Aoki J, Arai H, Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem. 2006 Sep 1;281(35):25822-30
1*	J:151374 Teichert AM, Scott JA, Robb GB, Zhou YQ, Zhu SN, Lem M, Keightley A, Steer BM, Schuh AC, Adamson SL, Cybulsky MI, Marsden PA, Endothelial nitric oxide synthase gene expression during murine embryogenesis: commencement of expression in the embryo occurs with the establishment of a unidirectional circulatory system. Circ Res. 2008 Jul 3;103(1):24-33
1*	J:64329 Welsh IC, O'Brien TP, Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse. Dev Biol. 2000 Sep 1;225(1):151-68
1*	J:148361 Xu K, Chong DC, Rankin SA, Zorn AM, Cleaver O, Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation. Dev Biol. 2009 May 15;329(2):269-79
1	J:174152 Xu K, Sacharidou A, Fu S, Chong DC, Skaug B, Chen ZJ, Davis GE, Cleaver O, Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling. Dev Cell. 2011 Apr 19;20(4):526-39
1	J:87724 Yoshitomi H, Zaret KS, Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development. 2004 Feb;131(4):807-17